Director, IT Strategy

Cyllene Therapeutics is a clinical-stage biotechnology company developing next-generation DNA medicines for the treatment of prevalent chronic and severe neurological disorders. We have developed our proprietary HERMES (Herpes-based Modular Expression System) platform that utilizes non-replicative herpes simplex virus type 1 (nrHSV-1) vectors engineered to deliver site-specific long-lasting therapies directly to target neurons while avoiding systemic exposure. Our lead product candidate, EG110A, has shown favorable safety and efficacy interim results in our first-in-human trial currently ongoing in four U.S. sites in patients with neurogenic detrusor overactivity (NDO)-related incontinence following spinal cord injury.

We believe our HERMES platform has the potential to overcome key limitations of conventional gene therapy approaches, including limited payload capacity, immunogenicity, off-target effects, challenges associated with repeat administration and high manufacturing costs, thereby providing us with potential opportunities to grow our pipeline of product candidates. Our second product candidate, EG142A, has now demonstrated encouraging preclinical activity in a series of animal models in different forms of chronic pain.

Job Description

We are looking for an experienced and hands‑on Director, IT Strategy to define and drive our IT strategy, supporting the growth of the company across France and the United States.

Working closely with leadership and business teams, this role will focus on developing a scalable, secure and efficient technology environment across three key pillars: Software, Hardware & Infrastructure, and Artificial Intelligence.

The ideal candidate combines strategic vision with a pragmatic, execution‑oriented mindset, bringing the ability to translate business needs into technology solutions while coordinating internal stakeholders and external partners.

Main responsibilities

• Define and implement an IT roadmap aligned with business priorities and company growth.
• Assess existing systems, identify improvement opportunities and recommend technology investments.
• Establish, in line with leadership appropriate IT governance, policies and processes to support scalability, security and operational efficiency.
• Coordinate IT projects, budgets and external technology partners.

Artificial Intelligence & Automation

• Develop a pragmatic AI adoption strategy aligned with business needs.
• Identify and prioritize relevant AI and automation use cases across the organization.
• Evaluate and facilitate the implementation of AI‑enabled tools and solutions.
• Promote responsible AI adoption, including data security, governance and employee enablement.

Software & Business Applications

• Oversee the evolution and optimization of the company’s software ecosystem, including business applications, SaaS platforms and collaboration tools.
• Support the selection, implementation and integration of technology solutions across business functions.
• Identify opportunities to streamline workflows, improve system interoperability and enhance operational efficiency.

Hardware, Infrastructure & Cybersecurity

• Coordinate the management and development of IT infrastructure, including devices, networks, cloud services and workplace technology.
• Contribute to the implementation of cybersecurity, data protection and business continuity best practices.
• Ensure reliable and consistent IT services across France and the US, working with external providers where appropriate.
• Anticipate infrastructure requirements to support organizational growth.

Key Qualifications

Education: Bachelor’s or Master’s degree in Information Technology, Computer Science, Engineering or a related field.

Professional experience

• 8–15 years of relevant experience in IT management, technology operations or digital transformation.
• Demonstrated experience developing and implementing IT strategies in a growing organization.
• Exposure to AI adoption, automation or technology transformation initiatives is desirable.
• Experience in biotechnology, life sciences or other regulated industries is a plus.
• Adaptable and comfortable to work in a fast‑paced and in a growing environment
• Collaborative, pragmatic, and outcome‑driven

Languages: English (spoken and written)

IT skills: Mac environment, Office 365 and professional software